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Des kinases cellulaires achèvent le processus de phosphorylation (conversion du monophosphate en triphosphate). In a host cell which carries nucleic acid encoding a transactivator fusion protein of the invention and a nucleotide sequence operatively linked to the tet operator sequence (ie, methotrexate induced liver disease gene of interest to be transcribed), high level transcription of the nucleotide sequence operatively linked to the tet operator sequence(s) does not occur in the absence of the substituted tetracycline compounds of the invention!
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